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MAJOR PAYNE DVD
MAJOR PAYNE DVD
Damon Wayans stars in Major Payne, a hilarious escapade that commands laughs aplenty! When peace breaks out in America, killing machine Major Benson Winifred Payne (Wayans) of the United States Marine Corps Special Forces is given his marching orders...to the unemployment line. Unable to cope with civilian life, Payne is thrust back into the military regimen as commander of the Madison Academy Junior ROTC. How does the military's most dangerous secret weapon discipline a few good men when none of them are even old enough to shave? Any way he wants! At least until the school counselor, Dr. Emily Walburn (Karen Parsons), joins his tour of duty...
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"p"Let's face facts here: You don't watch a movie like Major Payne for its artistic merit any more than you'd watch "i"Schindler's List for its comedy. If you go in thinking otherwise, you're bucking for a disappointment. So it's a pleasant surprise to discover that Major Payne is more entertaining than a barrel full of bad reviews would lead you to believe. It's a totally formulaic comedy about a bunch of misfit kids who turn into a crack squad of skillfully disciplined ROTC cadets, but Damon Wayans is spot-on hilarious in the title role as the hardened military bulldog who whips the little slackers into shape. Wayans plays the role as if killing and warfare were the only joys in life, and when he finds himself cast adrift without a military commission, a scene that directly parodies "i"Apocalypse Now lets you know that Wayans (who cowrote the script) is going to bring something new to this routine scenario. Major Payne's idea of a good bedtime story is to recall his worst battlefield horrors, and Wayans gives it just the right twist of comedy to put Payne's bullet-pierced heart in the right place--he's really just a good guy with an iron-clad exterior. The young recruits strut their stuff in the final round of their cadet competition (their marching rap is good for a solid laugh), and director Nick Castle keeps it all from becoming too stupid or over the top. It's arguably only for Wayans's most ardent fans, but as a send-up of all the great movie drill instructors, Major Payne is painlessly enjoyable. --Jeff Shannon
MAJOR PAYNE DVD
Open access journal of the Ferrata-Storti Foundation, a non-profit organization
Open access journal of the Ferrata-Storti Foundation, a non-profit organization
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This open-label, single-arm study investigated the long-term efficacy of tafasitamab plus lenalidomide in 81 patients with relapsed/refractory diffuse large B-cell lymphoma. The response rate was 57.5%, including complete responses in 40.0% of patients, and the median duration of response was 43.9 months. This treatment is a valuable option for patients not eligible for autologous stem-cell transplantation.
Grey zone lymphoma is a B-cell lymphoma, unclassifiable, with features intermediate between those of large B-cell lymphoma and classic Hodgkin lymphoma. The in-depth study of the two adolescent patients described in this case report expands the clinicopathological and genomic spectrum of this rare pediatric disease. Moreover, it provides information on their response to treatment.
The clinical picture of 56 patients with congenital amegakaryocytic thrombocytopenia due to MPL mutations was much more varied than previously thought. Twenty-five per cent of them had no signs of thrombocytopenia at birth, and 50% had non-hematologic defects. Pancytopenia developed in (nearly) all patients and hematopoietic stem-cell transplantation was effective in 87% of cases.
Sickle red blood cells exhibit abnormal adhesion to laminin mediated by Lu/BCAM protein at their surface. This study provides evidence of the involvement of oxidative stress in post-translational modifications of Lu/BCAM which impact the protein’s distribution and cis-interaction with glycophorin C at the cell surface activating its adhesive function in dense sickle red cells. The authors speculate that antioxidant drugs might attenuate this phenomenon.